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Inhibition of COX-2 Gene Expression

 COX-2 is an enzyme responsible for inflammation and pain. Natural compounds and pharmaceutical products can exhibit inhibition of cox 2 gene expression effects at two different levels. Due in part to their complexity, some natural products contain synergistic compounds that triggers the inhibition of COX-2 gene expression at both levels:

  1.  The expression (i.e. intracellular production) of the COX-2 enzyme;
  2. Once the enzyme is produced, products may inhibit the enzyme function.

NIS Labs performs testing of natural products at both levels, using cellular assays.  The testing of COX-2 expression is performed by pretreating cells with the natural product, then triggering an inflammatory reaction to increase the expression of COX-2 (i.e. the relative number of COX-2 enzymes per cell).  The expression is evaluated using intracellular staining for COX-2 enzyme, and measured by flow cytometry.


The testing of COX-2 enzymatic activity is tested in cell cultures by measuring the amount of prostaglandin production by the cells.

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