Cytokine Production
The balance between different cytokines is an important factor in immune regulation between predominantly pro- and anti-inflammatory immune responsiveness. Knowing whether a natural product induces or inhibits production of different cytokines in cell-based testing systems can assist in creating a portfolio on mechanisms of action.
NIS Labs performs testing for the following panel of cytokines, using cell culture supernatants from five-day cultures of peripheral blood mononuclear cells exposed to test products. To test direct versus synergistic effects, cells are treated both with a test product alone and in the presence of the known T cell mitogen PHA.
Th1 cytokines:
- IL-2,
- TNF-alpha,
- Interferon-gamma.
Th2 cytokines
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- IL-4,
- IL-6,
- IL-10.
